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5'-Hydroxy-5'-homoaristeromycin: Synthesis and antiviral properties.

ABSTRACT: Synthetically combining the C-4' side-chain structural features of the antiviral candidates 5'-methylaristeromycin and 5'-homoaristeromycin into a diastereomeric pair of C-4' side-chain dihydroxylated aristeromycins (6 and 7) is reported. Broad antiviral analyses of the both targets found promising effects towards HBV (6, 6.7??M and 7, 7.74??M) and HCMV (only 7, 0.72??M). No other activity was found. Neither of the diastereomers was cytotoxic in the assays performed.

SUBMITTER: Chen Q

PROVIDER: S-EPMC7126772 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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5'-Hydroxy-5'-homoaristeromycin: Synthesis and antiviral properties.

Chen Qi Q Liu Chong C Bowlin Terry L TL Schneller Stewart W SW

Bioorganic & medicinal chemistry letters 20180331 9

Synthetically combining the C-4' side-chain structural features of the antiviral candidates 5'-methylaristeromycin and 5'-homoaristeromycin into a diastereomeric pair of C-4' side-chain dihydroxylated aristeromycins (6 and 7) is reported. Broad antiviral analyses of the both targets found promising effects towards HBV (6, 6.7 μM and 7, 7.74 μM) and HCMV (only 7, 0.72 μM). No other activity was found. Neither of the diastereomers was cytotoxic in the assays performed. ...[more]

PMID: 29628328

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