Unknown

Dataset Information

0

New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2.


ABSTRACT: At present therapeutic options for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are very limited. We designed and synthesized three sets of small molecules using quinoline scaffolds. A series of quinoline conjugates (10a-l, 11a-c, and 12a-e) by incorporating 1,2,3-triazole were synthesized via a modified microwave-assisted click chemistry technique. Among the synthesized conjugates, 4-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-fluoro-2-(trifluoromethyl)quinoline (10g) and 6-fluoro-4-(2-(1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)ethoxy)-2-(trifluoromethyl)quinoline (12c) show high potency against SARS-CoV-2. The selectivity index (SI) of compounds 10g and 12c also indicates the significant efficacy compared to the reference drugs.

SUBMITTER: Seliem IA 

PROVIDER: S-EPMC8219945 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8426689 | biostudies-literature
| S-EPMC8241580 | biostudies-literature
| S-SCDT-10_1038-S44319-024-00189-4 | biostudies-other
| S-EPMC7996174 | biostudies-literature
| S-EPMC8566089 | biostudies-literature
| S-EPMC7969865 | biostudies-literature
| S-EPMC6072531 | biostudies-literature
| S-EPMC8071222 | biostudies-literature
| S-EPMC6273226 | biostudies-literature
| S-EPMC8435103 | biostudies-literature