Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC7126777 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Li Chuntian C Zhu Zixiang Z Du Xiaoli X Cao Weijun W Yang Fan F Zhang Xiangle X Feng Huanhuan H Li Dan D Zhang Keshan K Liu Xiangtao X Zheng Haixue H
Virology 20170626
The interferon-induced double-strand RNA activated protein kinase (PKR) plays important roles in host defense against viral infection. Here we demonstrate the significant antiviral role of PKR against foot-and-mouth disease virus (FMDV) and report that FMDV infection inhibits PKR expression and activation in porcine kidney (PK-15) cells. The viral nonstructural protein 3C proteinase (3C<sup>pro</sup>) is identified to be responsible for this inhibition. However, it is independent of the well-kno ...[more]