Ontology highlight
ABSTRACT:
SUBMITTER: Ryu YB
PROVIDER: S-EPMC7127101 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20100204 6
Quinone-methide triterpenes, celastrol (1), pristimerin (2), tingenone (3), and iguesterin (4) were isolated from Triterygium regelii and dihydrocelastrol (5) was synthesized by hydrogenation under palladium catalyst. Isolated quinone-methide triterpenes (1-4) and 5 were evaluated for SARS-CoV 3CL(pro) inhibitory activities and showed potent inhibitory activities with IC(50) values of 10.3, 5.5, 9.9, and 2.6 microM, respectively, whereas the corresponding 5 having phenol moiety was observed in l ...[more]