Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC7131928 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Yang Lu L Zhang Bin B Wang Xinju X Liu Zhenhua Z Li Juan J Zhang Shumiao S Gu Xiaoming X Jia Min M Guo Haitao H Feng Na N Fan Rong R Xie Manjiang M Pei Jianming J Chen Li L
Journal of cellular and molecular medicine 20200212 6
High-fat diet (HFD) leads to obesity, type II diabetes mellitus (T2DM) and increases the coincidence of cardiovascular diseases and cancer. Insulin resistance (IR) is considered as the 'common soil' of those diseases. Furthermore, people on HFD showed restrained glycolysis and enhanced fatty acid oxidation, which is the so-called metabolic reprogramming. However, the relationship between metabolic reprogramming and IR induced by HFD is still unclear. Here, we demonstrate that PANK1 and miR-107 w ...[more]