Ontology highlight
ABSTRACT:
SUBMITTER: Park SJ
PROVIDER: S-EPMC7132149 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Park Seung Ju SJ Park Hoyong H Kim Min-Gyu MG Zhang Seungjae S Park Seung Eun SE Kim Seyun S Chung ChiHye C
iScience 20200322 4
The coordination of synaptic vesicle exocytosis and endocytosis supports neurotransmitter release from presynaptic terminals. Although inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP<sub>7</sub>), are versatile signaling metabolites in many biological events, physiological actions of 5-IP<sub>7</sub> on synaptic membrane vesicle trafficking remain unclear. Here, we investigated the role of 5-IP<sub>7</sub> in synaptic transmission in hippocampal brain slices from ino ...[more]