Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC7132159 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Zhang Lu L Xie Bowen B Qiu Yanfang Y Jing Di D Zhang Jing J Duan Yumei Y Li Zhi Z Fan Ming M He Jiang J Qiu Yuanzheng Y Tan Rong R Li Jian Jian JJ Sun Lun-Quan LQ
iScience 20200320 4
Tumor acquired radioresistance remains as the major limit in cancer radiotherapy (RT). Rab25, a receptor recycling protein, has been reported to be enhanced in tumors with aggressive phenotype and chemotherapy resistance. In this study, elevated Rab25 expression was identified in an array of radioresistant human cancer cell lines, in vivo radioresistant xenograft tumors. Clinical investigation confirmed that Rab25 expression was also associated with a worse prognosis in patients with lung adenoc ...[more]