Comparative Molecular Life History of Spontaneous Canine and Human Gliomas.
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ABSTRACT:
SUBMITTER: Amin SB
PROVIDER: S-EPMC7132629 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Comparative Molecular Life History of Spontaneous Canine and Human Gliomas.
Amin Samirkumar B SB Anderson Kevin J KJ Boudreau C Elizabeth CE Martinez-Ledesma Emmanuel E Kocakavuk Emre E Johnson Kevin C KC Barthel Floris P FP Varn Frederick S FS Kassab Cynthia C Ling Xiaoyang X Kim Hoon H Barter Mary M Lau Ching C CC Ngan Chew Yee CY Chapman Margaret M Koehler Jennifer W JW Long James P JP Miller Andrew D AD Miller C Ryan CR Porter Brian F BF Rissi Daniel R DR Mazcko Christina C LeBlanc Amy K AK Dickinson Peter J PJ Packer Rebecca A RA Taylor Amanda R AR Rossmeisl John H JH Woolard Kevin D KD Heimberger Amy B AB Levine Jonathan M JM Verhaak Roel G W RGW
Cancer cell 20200201 2
Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of human pediatric and adult gliomas to characterize evolutionarily conserved mammalian mutational processes in gliomagenesis. Employing whole-genome, exome, transcriptome, and methylation sequencing of 83 canine gliomas, we found alterations shared between canine and human gliomas such as the receptor tyrosine ...[more]
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