Role of intrinsic disorder in muscle sarcomeres.
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ABSTRACT:
SUBMITTER: Tolkatchev D
PROVIDER: S-EPMC7134574 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Role of intrinsic disorder in muscle sarcomeres.
Tolkatchev Dmitri D Smith Garry E GE Kostyukova Alla S AS
Progress in molecular biology and translational science 20190413
The role and utility of intrinsically disordered regions (IDRs) is reviewed for two groups of sarcomeric proteins, such as members of tropomodulin/leiomodin (Tmod/Lmod) protein homology group and myosin binding protein C (MyBP-C). These two types of sarcomeric proteins represent very different but strongly interdependent functions, being responsible for maintaining structure and operation of the muscle sarcomere. The role of IDRs in the formation of complexes between thin filaments and Tmods/Lmo ...[more]
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