Ontology highlight
ABSTRACT:
SUBMITTER: Leemans M
PROVIDER: S-EPMC7135905 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Leemans Margaux M Galicia Christian C Deyaert Egon E Daems Elise E Krause Linda L Paesmans Jone J Pardon Els E Steyaert Jan J Kortholt Arjan A Sobott Frank F Klostermeier Dagmar D Versées Wim W
The Biochemical journal 20200401 7
Mutations in the Parkinson's disease (PD)-associated protein leucine-rich repeat kinase 2 (LRRK2) commonly lead to a reduction of GTPase activity and increase in kinase activity. Therefore, strategies for drug development have mainly been focusing on the design of LRRK2 kinase inhibitors. We recently showed that the central RocCOR domains (Roc: Ras of complex proteins; COR: C-terminal of Roc) of a bacterial LRRK2 homolog cycle between a dimeric and monomeric form concomitant with GTP binding and ...[more]