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The prevalence of altered body image in patients with primary brain tumors: an understudied population.

ABSTRACT: PURPOSE:Body image (BI) is an important issue for cancer patients, as patients with BI concerns are susceptible to depression, anxiety, difficulty coping, and poor quality of life (QoL). While this concern has been documented in patients with other malignancies, no data exists of this QoL issue in patients with primary brain tumors (PBT). METHODS:A cross-sectional survey of 100 PBT patients was conducted on an IRB approved prospective protocol using structured questionnaires. Participants completed the body image scale (BIS), Appearance Scheme Inventory Revised (ASI-R), MD Anderson Symptom Inventory Brain Tumor (MDASI-BT), and Patient-Reported Outcomes Measurement Information System (PROMIS) Depression, Anxiety, and Psychosocial Impact Positive measures. RESULTS:The prevalence of clinically significant body image dissatisfaction (BIS???10) was 28% (95% CI 19-37%), median BIS score was 5 (range 0-27). The median ASI-R composite score was 2.9 (range 1.5-4.7). BIS was significantly correlated with the ASI-R (r?=?0.53, 95% CI 0.37 to 0.65). The mean PROMIS Depression score was 48.4 (SD?=?8.9), PROMIS Anxiety score was 49.4 (SD?=?9.9), and PROMIS Psychosocial Illness Impact Positive score was 48.9 (SD?=?9.7). BIS was significantly correlated with age, and trended with BMI and sex. The PROMIS Psychosocial Illness Impact Positive and PROMIS Anxiety scores were the most strongly related to BIS. CONCLUSIONS:This study, the first to explore altered body image in PBT patients, revealed clinically significant body image dissatisfaction in nearly 1/3 of patients, similar to other malignancies. These findings underscore the potential contribution of disease and treatment-related body image concerns on psychosocial wellbeing in patients with PBT.

SUBMITTER: Rowe L

PROVIDER: S-EPMC7136178 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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The prevalence of altered body image in patients with primary brain tumors: an understudied population.

Rowe Lindsay L Vera Elizabeth E Acquaye Alvina A Crandon Sonja S Shah Veeraj V Bryla Christine C Wu Jing J Wall Kathleen K Siegel Christine C Reyes Jennifer J Penas-Prado Marta M Leggiero Nicole N Cordova Christine C Burton Eric E Antony Ramya R Boris Lisa L Aboud Orwa O Vyas Yamini Y Mathen Peter P Gilbert Mark M Camphausen Kevin K Mendoza Tito T Armstrong Terri T

Journal of neuro-oncology 20200224 2

<h4>Purpose</h4>Body image (BI) is an important issue for cancer patients, as patients with BI concerns are susceptible to depression, anxiety, difficulty coping, and poor quality of life (QoL). While this concern has been documented in patients with other malignancies, no data exists of this QoL issue in patients with primary brain tumors (PBT).<h4>Methods</h4>A cross-sectional survey of 100 PBT patients was conducted on an IRB approved prospective protocol using structured questionnaires. Part ...[more]

PMID: 32096067

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Project description:Understanding complex body-brain processes and the interplay between adipose tissue and brain health is important for understanding comorbidity between psychiatric and cardiometabolic disorders. We investigated associations between brain structure and anthropometric and body composition measures using brain magnetic resonance imaging (MRI; n = 24,728) and body MRI (n = 4973) of generally healthy participants in the UK Biobank. We derived regional and global measures of brain morphometry using FreeSurfer and tested their association with (i) anthropometric measures, and (ii) adipose and muscle tissue measured from body MRI. We identified several significant associations with small effect sizes. Anthropometric measures showed negative, nonlinear, associations with cerebellar/cortical gray matter, and brain stem structures, and positive associations with ventricular volumes. Subcortical structures exhibited mixed effect directionality, with strongest positive association for accumbens. Adipose tissue measures, including liver fat and muscle fat infiltration, were negatively associated with cortical/cerebellum structures, while total thigh muscle volume was positively associated with brain stem and accumbens. Regional investigations of cortical area, thickness, and volume indicated widespread and largely negative associations with anthropometric and adipose tissue measures, with an opposite pattern for thigh muscle volume. Self-reported diabetes, hypertension, or hypercholesterolemia were associated with brain structure. The findings provide new insight into physiological body-brain associations suggestive of shared mechanisms between cardiometabolic risk factors and brain health. Whereas the causality needs to be determined, the observed patterns of body-brain relationships provide a foundation for understanding the underlying mechanisms linking psychiatric disorders with obesity and cardiovascular disease, with potential for the development of new prevention strategies.

Dataset Information

The prevalence of altered body image in patients with primary brain tumors: an understudied population.

Publications

The prevalence of altered body image in patients with primary brain tumors: an understudied population.

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