Unknown

Dataset Information

0

Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy.


ABSTRACT: Background:Both pre-operative anemia and perioperative (intra- and/or post-operative) blood transfusion have been reported to increase post-operative complications in patients with colon cancer undergoing colectomy. However, their joint effect has not been investigated. The purpose of this study was to evaluate the joint effect of pre-operative anemia and perioperative blood transfusion on the post-operative outcome of colon-cancer patients after colectomy. Methods:We identified patients from the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database 2006-2016 who underwent colectomy for colon cancer. Multivariate logistic regression analysis was employed to assess the independent and joint effects of anemia and blood transfusion on patient outcomes. Results:A total of 35,863 patients-18,936 (52.8%) with left-side colon cancer (LCC) and 16,927 (47.2%) with right-side colon cancer (RCC)-were identified. RCC patients were more likely to have mild anemia (62.7%) and severe anemia (2.9%) than LCC patients (40.2% mild anemia and 1.4% severe anemia). A total of 2,661 (7.4%) of all patients (1,079 [5.7%] with LCC and 1,582 [9.3%] with RCC) received a perioperative blood transfusion. Overall, the occurrence rates of complications were comparable between LCC and RCC patients (odds ratio [OR]?=?1.01; 95% confidence interval [CI]?=?0.95-1.07; P?=?0.750). There were significant joint effects of anemia and transfusion on complications and the 30-day death rate (P for interaction: 0.010). Patients without anemia who received a transfusion had a higher risk of any complications (LCC, OR?=?3.51; 95% CI?=?2.55-4.85; P?

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7136710 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy.

Liu Zheng Z   Luo Jia-Jun JJ   Pei Kevin Y KY   Khan Sajid A SA   Wang Xiao-Xu XX   Zhao Zhi-Xun ZX   Yang Ming M   Johnson Caroline H CH   Wang Xi-Shan XS   Zhang Yawei Y  

Gastroenterology report 20190809 2


<h4>Background</h4>Both pre-operative anemia and perioperative (intra- and/or post-operative) blood transfusion have been reported to increase post-operative complications in patients with colon cancer undergoing colectomy. However, their joint effect has not been investigated. The purpose of this study was to evaluate the joint effect of pre-operative anemia and perioperative blood transfusion on the post-operative outcome of colon-cancer patients after colectomy.<h4>Methods</h4>We identified p  ...[more]

Similar Datasets

| S-EPMC6197687 | biostudies-literature
| S-EPMC10486190 | biostudies-literature
| S-EPMC7503677 | biostudies-literature
| S-EPMC5546394 | biostudies-literature
| S-EPMC7241000 | biostudies-literature
| S-EPMC6588057 | biostudies-literature
| S-EPMC9514715 | biostudies-literature
| S-EPMC4234031 | biostudies-literature
| S-EPMC6917537 | biostudies-literature
| S-EPMC2911729 | biostudies-literature