Ontology highlight
ABSTRACT:
SUBMITTER: Serena C
PROVIDER: S-EPMC7137346 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Serena Carolina C Millan Monica M Ejarque Miriam M Saera-Vila Alfonso A Maymó-Masip Elsa E Núñez-Roa Catalina C Monfort-Ferré Diandra D Terrón-Puig Margarida M Bautista Michelle M Menacho Margarita M Martí Marc M Espin Eloy E Vendrell Joan J Fernández-Veledo Sonia S
Clinical epigenetics 20200406 1
<h4>Background</h4>Crohn's disease (CD) is characterized by persistent inflammation and ulceration of the small or large bowel, and expansion of mesenteric adipose tissue, termed creeping fat (CF). We previously demonstrated that human adipose-derived stem cells (hASCs) from CF of patients with CD exhibit dysfunctional phenotypes, including a pro-inflammatory profile, high phagocytic capacity, and weak immunosuppressive properties. Importantly, these phenotypes persist in patients in remission a ...[more]