Ontology highlight
ABSTRACT:
SUBMITTER: Gebauer JM
PROVIDER: S-EPMC7137805 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Gebauer Jan M JM Flachsenberg Florian F Windler Cordula C Richer Barbara B Baumann Ulrich U Seeger Karsten K
FEBS open bio 20200314 4
Type VII collagen is an extracellular matrix protein, which is important for skin stability; however, detailed information at the molecular level is scarce. The second vWFA (von Willebrand factor type A) domain of type VII collagen mediates important interactions, and immunization of mice induces skin blistering in certain strains. To understand vWFA2 function and the pathophysiological mechanisms leading to skin blistering, we structurally characterized this domain by X-ray crystallography and ...[more]