Ontology highlight
ABSTRACT:
SUBMITTER: Hsieh YP
PROVIDER: S-EPMC7138332 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Hsieh Yu-Ying Phoebe YP Makrantoni Vasso V Robertson Daniel D Marston Adèle L AL Murray Andrew W AW
PLoS biology 20200310 3
The role of proteins often changes during evolution, but we do not know how cells adapt when a protein is asked to participate in a different biological function. We forced the budding yeast, Saccharomyces cerevisiae, to use the meiosis-specific kleisin, recombination 8 (Rec8), during the mitotic cell cycle, instead of its paralog, Scc1. This perturbation impairs sister chromosome linkage, advances the timing of genome replication, and reduces reproductive fitness by 45%. We evolved 15 parallel ...[more]