Ontology highlight
ABSTRACT:
SUBMITTER: Zhao H
PROVIDER: S-EPMC7138573 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Zhao Hong H Li Shuo S Li Zhuo Z Yang Shuo S Li Dandan D Zheng Jiaolin J Gao Hongmei H Yun Ling L Gu YingLi Y Li Longxuan L Zhao Jing J Fu Yuan Y
Aging 20200325 6
Alzheimer's disease (AD) is associated with the accumulation and deposition of a beta-amyloid (Αβ) peptide in the brain, resulting in increased neuroinflammation and synaptic dysfunction. Intranasal delivery of targeted drugs to the brain represents a noninvasive pathway that bypasses the blood-brain barrier and minimizes systemic exposure. The aim of this study was to evaluate the therapeutic effect of intranasally delivered 9-cis retinoic acid (RA) on the neuropathology of an AD mouse model. H ...[more]