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Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data.

ABSTRACT: Vaccine therapies for treatment and prevention of cancer have seen modest degrees of efficacy with wide variation related to the tumor type, vaccine type, adjuvants and clinical setting for their study. Over the course of the last two decades, various peptide vaccines for breast cancer have been studied. The current leading peptide vaccine for human application is a HER2-based vaccine known as Nelipepimut-S, which has demonstrated immune activity and promising clinical activity in some settings. This review covers the development of this newer peptide vaccine for both HER2 amplified and non-amplified breast cancer.

SUBMITTER: Dillon PM

PROVIDER: S-EPMC7138626 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data.

Dillon Patrick M PM Brenin Christiana M CM Slingluff Craig L CL

Breast cancer (Dove Medical Press) 20200403

Vaccine therapies for treatment and prevention of cancer have seen modest degrees of efficacy with wide variation related to the tumor type, vaccine type, adjuvants and clinical setting for their study. Over the course of the last two decades, various peptide vaccines for breast cancer have been studied. The current leading peptide vaccine for human application is a HER2-based vaccine known as Nelipepimut-S, which has demonstrated immune activity and promising clinical activity in some settings. ...[more]

PMID: 32308474

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Dataset Information

Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data.

Publications

Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data.

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