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Occurrence of pendelluft under pressure support ventilation in patients who failed a spontaneous breathing trial: an observational study.


ABSTRACT: BACKGROUND:Pendelluft, the movement of gas within different lung regions, is present in animal models of assisted mechanical ventilation and associated with lung overstretching. Due to rebreathing of CO2 as compared to fresh gas, pendelluft might reduce ventilatory efficiency possibly exacerbating patient's respiratory workload during weaning. Our aim was to measure pendelluft by electrical impedance tomography (EIT) in patients who failed a spontaneous breathing trial (SBT). METHODS:This is an observational study conducted in a general intensive care unit of a tertiary-level teaching hospital. EIT signal was recorded in 20 patients while pressure support (PS) ventilation was progressively reduced from clinical level (baseline) to 2 cmH2O, as in an SBT; four ventral-to-dorsal lung regions of interest were identified for pendelluft measurement. A regional gas movement (>?6 mL) occurring in a direction opposite to the global EIT signal was considered diagnostic for high pendelluft. RESULTS:Eight patients out of 20 (40%) were classified as high-pendelluft; baseline clinical characteristics did not differ between high- and low-pendelluft patients. At PS reduction, pendelluft and EtCO2 increased more in the high-pendelluft group (p?

SUBMITTER: Coppadoro A 

PROVIDER: S-EPMC7138895 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Occurrence of pendelluft under pressure support ventilation in patients who failed a spontaneous breathing trial: an observational study.

Coppadoro Andrea A   Grassi Alice A   Giovannoni Cecilia C   Rabboni Francesca F   Eronia Nilde N   Bronco Alfio A   Foti Giuseppe G   Fumagalli Roberto R   Bellani Giacomo G  

Annals of intensive care 20200407 1


<h4>Background</h4>Pendelluft, the movement of gas within different lung regions, is present in animal models of assisted mechanical ventilation and associated with lung overstretching. Due to rebreathing of CO<sub>2</sub> as compared to fresh gas, pendelluft might reduce ventilatory efficiency possibly exacerbating patient's respiratory workload during weaning. Our aim was to measure pendelluft by electrical impedance tomography (EIT) in patients who failed a spontaneous breathing trial (SBT).<  ...[more]

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