Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt M
PROVIDER: S-EPMC7139388 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200317 6
Human 17β-hydroxysteroid dehydrogenase type 10 is a multifunctional protein involved in many enzymatic and structural processes within mitochondria. This enzyme was suggested to be involved in several neurological diseases, e.g., mental retardation, Parkinson's disease, or Alzheimer's disease, in which it was shown to interact with the amyloid-beta peptide. We prepared approximately 60 new compounds based on a benzothiazolyl scaffold and evaluated their inhibitory ability and mechanism of action ...[more]