Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi T
PROVIDER: S-EPMC7139586 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Takahashi Toshio T Shiraishi Akira A
International journal of molecular sciences 20200316 6
The ability of stem cells to divide and differentiate is necessary for tissue repair and homeostasis. Appropriate spatial and temporal mechanisms are needed. Local intercellular signaling increases expression of specific genes that mediate and maintain differentiation. Diffusible signaling molecules provide concentration-dependent induction of specific patterns of cell types or regions. Differentiation of adjacent cells, on the other hand, requires cell-cell contact and subsequent signaling. The ...[more]