Biology and Therapeutic Targets of Colorectal Serrated Adenocarcinoma; Clues for a Histologically Based Treatment against an Aggressive Tumor.
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ABSTRACT:
SUBMITTER: Alburquerque-Gonzalez B
PROVIDER: S-EPMC7139914 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Biology and Therapeutic Targets of Colorectal Serrated Adenocarcinoma; Clues for a Histologically Based Treatment against an Aggressive Tumor.
Alburquerque-González Begoña B López-Calderón Fernando F FF López-Abellán María Dolores MD Esteban-Gil Ángel Á García-Solano José J Conesa-Zamora Pablo P
International journal of molecular sciences 20200314 6
Serrated adenocarcinoma (SAC) is a tumor recognized by the WHO as a histological subtype accounting for around 9% of colorectal carcinomas. Compared to conventional carcinomas, SACs are characterized by a worse prognosis, weak development of the immune response, an active invasive front and a frequent resistance to targeted therapy due to a high occurrence of KRAS or BRAF mutation. Nonetheless, several high-throughput studies have recently been carried out unveiling the biology of this cancer an ...[more]
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