Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle.
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ABSTRACT:
SUBMITTER: Park SS
PROVIDER: S-EPMC7139950 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle.
Park Sung Sup SS Seo Young-Kyo YK
International journal of molecular sciences 20200312 6
Both glucose and free fatty acids (FFAs) are used as fuel sources for energy production in a living organism. Compelling evidence supports a role for excess fatty acids synthesized in intramuscular space or dietary intermediates in the regulation of skeletal muscle function. Excess FFA and lipid droplets leads to intramuscular accumulation of lipid intermediates. The resulting downregulation of the insulin signaling cascade prevents the translocation of glucose transporter to the plasma membrane ...[more]
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