From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme.
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ABSTRACT:
SUBMITTER: Swenson SA
PROVIDER: S-EPMC7140478 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme.
Swenson Samantha A SA Moore Courtney M CM Marcero Jason R JR Medlock Amy E AE Reddi Amit R AR Khalimonchuk Oleh O
Cells 20200229 3
Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the biochemical aspects of heme biosynthetic reactions are well understood, the trafficking of newly synthesized heme-a highly reactive and inherently toxic compound-and its subsequent delivery to target p ...[more]
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