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Gene expression responses to anti-tuberculous drugs in a whole blood model.

ABSTRACT: BACKGROUND:There is a need for better tools to evaluate new or repurposed TB drugs. The whole blood bactericidal activity (WBA) assay has been advocated for this purpose. We investigated whether transcriptional responses in the WBA assay resemble TB responses in vivo, and whether the approach might additionally reveal mechanisms of action. RESULTS:1422 of 1798 (79%) of differentially expressed genes in WBA incubated with the standard combination of rifampicin, isoniazid, pyrazinamide and ethambutol were also expressed in sputum (P 

SUBMITTER: Kwan PKW 

PROVIDER: S-EPMC7140558 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Gene expression responses to anti-tuberculous drugs in a whole blood model.

Kwan Philip Kam Weng PKW   Lin Wenwei W   Naim Ahmad Nazri Mohamed ANM   Periaswamy Balamurugan B   De Sessions Paola Florez PF   Hibberd Martin L ML   Paton Nicholas I NI  

BMC microbiology 20200407 1

<h4>Background</h4>There is a need for better tools to evaluate new or repurposed TB drugs. The whole blood bactericidal activity (WBA) assay has been advocated for this purpose. We investigated whether transcriptional responses in the WBA assay resemble TB responses in vivo, and whether the approach might additionally reveal mechanisms of action.<h4>Results</h4>1422 of 1798 (79%) of differentially expressed genes in WBA incubated with the standard combination of rifampicin, isoniazid, pyrazinam  ...[more]

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