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Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification.


ABSTRACT: Vascular calcification is the pathological deposition of calcium/phosphate in the vascular system and is closely associated with cardiovascular morbidity and mortality. Here, we investigated the role of gastrin-releasing peptide (GRP) in phosphate-induced vascular calcification and its potential regulatory mechanism. We found that the silencing of GRP gene and treatment with the GRP receptor antagonist, RC-3095, attenuated the inorganic phosphate-induced calcification of vascular smooth muscle cells (VSMCs). This attenuation was caused by inhibiting phenotype change, apoptosis and matrix vesicle release in VSMCs. Moreover, the treatment with RC-3095 effectively ameliorated phosphate-induced calcium deposition in rat aortas ex vivo and aortas of chronic kidney disease in mice in vivo. Therefore, the regulation of the GRP-GRP receptor axis may be a potential strategy for treatment of diseases associated with excessive vascular calcification.

SUBMITTER: Park HJ 

PROVIDER: S-EPMC7140688 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification.

Park Hyun-Joo HJ   Kim Yeon Y   Kim Mi-Kyoung MK   Hwang Jae Joon JJ   Kim Hyung Joon HJ   Bae Soo-Kyung SK   Bae Moon-Kyoung MK  

Cells 20200317 3


Vascular calcification is the pathological deposition of calcium/phosphate in the vascular system and is closely associated with cardiovascular morbidity and mortality. Here, we investigated the role of gastrin-releasing peptide (GRP) in phosphate-induced vascular calcification and its potential regulatory mechanism. We found that the silencing of GRP gene and treatment with the GRP receptor antagonist, RC-3095, attenuated the inorganic phosphate-induced calcification of vascular smooth muscle c  ...[more]

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