Ontology highlight
ABSTRACT:
SUBMITTER: Annageldiyev C
PROVIDER: S-EPMC7140985 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Annageldiyev Charyguly C Tan Su-Fern SF Thakur Shreya S Dhanyamraju Pavan Kumar PK Ramisetti Srinivasa R SR Bhadauria Preeti P Schick Jacob J Zeng Zheng Z Sharma Varun V Dunton Wendy W Dovat Sinisa S Desai Dhimant D Zheng Hong H Feith David J DJ Loughran Thomas P TP Amin Shantu S Sharma Arun K AK Claxton David D Sharma Arati A
Frontiers in oncology 20200401
Acute myeloid leukemia is a heterogeneous disease with a 5-year survival rate of 28.3%, and current treatment options constrained by dose-limiting toxicities. One of the key signaling pathways known to be frequently activated and dysregulated in AML is PI3K/AKT. Its dysregulation is associated with aggressive cell growth and drug resistance. We investigated the activity of Phenybutyl isoselenocyanate (ISC-4) in primary cells obtained from newly diagnosed AML patients, diverse AML cell lines, and ...[more]