Ontology highlight
ABSTRACT:
SUBMITTER: Cohn GM
PROVIDER: S-EPMC7142217 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Cohn Gabriel M GM Liefwalker Daniel F DF Langer Ellen M EM Sears Rosalie C RC
Frontiers in cell and developmental biology 20200402
PIN1 is a phosphorylation-directed member of the peptidyl-prolyl <i>cis</i>/<i>trans</i> isomerase (PPIase) family that facilitates conformational changes in phosphorylated targets such as c-MYC (MYC). Following signaling events that mediate phosphorylation of MYC at Serine 62, PIN1 establishes structurally distinct pools of MYC through its <i>trans-cis</i> and <i>cis-trans</i> isomerization activity at Proline 63. Through these isomerization steps, PIN1 functionally regulates MYC's stability, t ...[more]