Ontology highlight
ABSTRACT:
SUBMITTER: Capietto AH
PROVIDER: S-EPMC7144530 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Capietto Aude-Hélène AH Jhunjhunwala Suchit S Pollock Samuel B SB Lupardus Patrick P Wong Jim J Hänsch Lena L Cevallos James J Chestnut Yajun Y Fernandez Ajay A Lounsbury Nicolas N Nozawa Tamaki T Singh Manmeet M Fan Zhiyuan Z de la Cruz Cecile C CC Phung Qui T QT Taraborrelli Lucia L Haley Benjamin B Lill Jennie R JR Mellman Ira I Bourgon Richard R Delamarre Lélia L
The Journal of experimental medicine 20200401 4
Tumor-specific mutations can generate neoantigens that drive CD8 T cell responses against cancer. Next-generation sequencing and computational methods have been successfully applied to identify mutations and predict neoantigens. However, only a small fraction of predicted neoantigens are immunogenic. Currently, predicted peptide binding affinity for MHC-I is often the major criterion for prioritizing neoantigens, although little progress has been made toward understanding the precise functional ...[more]