Ontology highlight
ABSTRACT:
SUBMITTER: Lin CC
PROVIDER: S-EPMC7144912 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Lin Chien-Chu CC Chen Yi-Ping YP Yang Wei-Zen WZ Shen James C K JCK Yuan Hanna S HS
Nucleic acids research 20200401 7
DNA methyltransferases are primary enzymes for cytosine methylation at CpG sites of epigenetic gene regulation in mammals. De novo methyltransferases DNMT3A and DNMT3B create DNA methylation patterns during development, but how they differentially implement genomic DNA methylation patterns is poorly understood. Here, we report crystal structures of the catalytic domain of human DNMT3B-3L complex, noncovalently bound with and without DNA of different sequences. Human DNMT3B uses two flexible loop ...[more]