Ontology highlight
ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC7144948 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Wang Fengting F Li Pan P Shao Yuan Y Li Yanyan Y Zhang Kai K Li Miaomiao M Wang Rong R Zheng Shuo S Wang Yingying Y Song Sen S Feng Shiguo S Liu Fei F Xiao Wei W Li Xialu X
Nucleic acids research 20200401 7
REV3L, the catalytic subunit of DNA polymerase ζ (Pol ζ), is indispensable for translesion DNA synthesis, which protects cells from deleterious DNA lesions resulting from various intrinsic and environmental sources. However, REV3L lacks a proofreading exonuclease activity and consequently bypasses DNA lesions at the expense of increased mutations, which poses a severe threat to genome stability. Here we report a site-specific proteolytic event of human REV3L. We show that REV3L is cleaved by a t ...[more]