Ontology highlight
ABSTRACT:
SUBMITTER: Kondacs LA
PROVIDER: S-EPMC7145296 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Kondacs Laszlo A LA Orenga Sylvain S Anderson Rosaleen J RJ Marrs Emma C L ECL Perry John D JD Gray Mark M
Molecules (Basel, Switzerland) 20200313 6
In clinical culture media inoculated with patient samples, selective inhibition of commensal bacteria is essential for accurate diagnosis and effective treatment, as they can mask the presence of pathogenic bacteria. The alanine analogue, 1-aminoethyltetrazole was investigated as a potential alanine racemase inhibitor. For effective uptake and enhanced and selective antibacterial activity, a library of C-terminal 1-aminoethyltetrazole containing di- and oligopeptides were synthesized by solid ph ...[more]