Specificity of protein-DNA interactions in hypersaline environment: structural studies on complexes of Halobacterium salinarum oxidative stress-dependent protein hsRosR.
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ABSTRACT:
SUBMITTER: Kutnowski N
PROVIDER: S-EPMC7145548 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Specificity of protein-DNA interactions in hypersaline environment: structural studies on complexes of Halobacterium salinarum oxidative stress-dependent protein hsRosR.
Kutnowski Nitzan N Shmulevich Fania F Davidov Geula G Shahar Anat A Bar-Zvi Dudy D Eichler Jerry J Zarivach Raz R Shaanan Boaz B
Nucleic acids research 20190901 16
Interactions between proteins and DNA are crucial for all biological systems. Many studies have shown the dependence of protein-DNA interactions on the surrounding salt concentration. How these interactions are maintained in the hypersaline environments that halophiles inhabit remains puzzling. Towards solving this enigma, we identified the DNA motif recognized by the Halobactrium salinarum ROS-dependent transcription factor (hsRosR), determined the structure of several hsRosR-DNA complexes and ...[more]
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