Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt TT
PROVIDER: S-EPMC7145683 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Schmidt Tobias T TT Sharma Sushma S Reyes Gloria X GX Kolodziejczak Anna A Wagner Tina T Luke Brian B Hofer Anders A Chabes Andrei A Hombauer Hans H
Nucleic acids research 20200101 1
The accumulation of mutations is frequently associated with alterations in gene function leading to the onset of diseases, including cancer. Aiming to find novel genes that contribute to the stability of the genome, we screened the Saccharomyces cerevisiae deletion collection for increased mutator phenotypes. Among the identified genes, we discovered MET7, which encodes folylpolyglutamate synthetase (FPGS), an enzyme that facilitates several folate-dependent reactions including the synthesis of ...[more]