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Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study.


ABSTRACT: This study aimed to evaluate the association between optical coherence tomography (OCT)-measured retinal layer thickness parameters with clinical and patient-centred visual outcomes in healthy eyes. Participants aged 40 and above were recruited from the Singapore Epidemiology of Eye Diseases Study, a multi-ethnic population-based study. Average macular, ganglion cell-inner plexiform layer (GCIPL), and outer retinal thickness parameters were obtained using the Cirrus High Definition-OCT. Measurements of best-corrected visual acuity (BCVA) and 11-item visual functioning questionnaire (VF-11) were performed. Associations between macular thickness parameters, with BCVA and Rasch-transformed VF-11 scores (in logits) were assessed using multivariable linear regression models with generalized estimating equations, adjusted for relevant confounders. 4,540 subjects (7,744 eyes) with a mean age of 58.8?±?8.6 years were included. The mean BCVA (LogMAR) was 0.10?±?0.11 and mean VF-11 score was 5.20?±?1.29. In multivariable regression analysis, thicker macula (per 20?µm; ??=?-0.009) and GCIPL (per 20?µm; ??=?-0.031) were associated with better BCVA (all p???0.001), while thicker macula (per 20?µm; ??=?0.04) and GCIPL (per 20?µm, ??=?0.05) were significantly associated with higher VF-11 scores (all p?

SUBMITTER: Poh S 

PROVIDER: S-EPMC7145798 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study.

Poh Stanley S   Tham Yih-Chung YC   Chee Miao Li ML   Dai Wei W   Majithia Shivani S   Soh Zhi Da ZD   Fenwick Eva K EK   Tao Yijin Y   Thakur Sahil S   Rim Tyler Hyungtaek TH   Sabanayagam Charumathi C   Cheng Ching-Yu CY  

Scientific reports 20200409 1


This study aimed to evaluate the association between optical coherence tomography (OCT)-measured retinal layer thickness parameters with clinical and patient-centred visual outcomes in healthy eyes. Participants aged 40 and above were recruited from the Singapore Epidemiology of Eye Diseases Study, a multi-ethnic population-based study. Average macular, ganglion cell-inner plexiform layer (GCIPL), and outer retinal thickness parameters were obtained using the Cirrus High Definition-OCT. Measurem  ...[more]

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