Ontology highlight
ABSTRACT:
SUBMITTER: Tutino V
PROVIDER: S-EPMC7146266 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Tutino Valeria V Gigante Isabella I Scavo Maria Principia MP Refolo Maria Grazia MG Nunzio Valentina De V Milella Rosa Anna RA Caruso Maria Gabriella MG Notarnicola Maria M
Nutrients 20200304 3
The polyphenolic compounds present in grape extracts have chemopreventive and anticancer properties. Here, we studied the ability of two grape skin extracts (GSEs), Autumn Royal and Egnatia, to influence the cell motility and membrane fluidity regulated by the enzyme Stearoyl-CoA desaturase-1 (SCD1) which increases with the cancer aggressiveness. Caco2 and SW480 human colon cancer cell lines were treated with increasing concentrations of GSEs to evaluate cell proliferation and motility. SCD1 lev ...[more]