Ontology highlight
ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC7146989 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Yu Xinyou X Gao Feng F Li Wei W Zhou Li L Liu Wenbin W Li Ming M
Journal of experimental & clinical cancer research : CR 20200410 1
<h4>Background</h4>Epidermal growth factor receptor (EGFR) activating mutations play crucial roles in the tumorigenesis of human non-small cell lung cancer (NSCLC). The mechanism regarding how EGFR signaling regulates myeloid cell leukemia sequence 1 (Mcl-1) protein stability and ubiquitination remains undefined.<h4>Methods</h4>MTS assay was used for natural product library screening. The effect of formononetin (Formo) on NSCLC cells was determined by MTS assay and soft agar assay. Molecular mod ...[more]