Ontology highlight
ABSTRACT:
SUBMITTER: Xin X
PROVIDER: S-EPMC7147381 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Xin Xing X Wen Ti T Gong Li-Bao LB Deng Ming-Ming MM Hou Ke-Zuo KZ Xu Lu L Shi Sha S Qu Xiu-Juan XJ Liu Yun-Peng YP Che Xiao-Fang XF Teng Yue-E YE
Frontiers in oncology 20200403
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, which is very difficult to treat and commonly develops resistance to chemotherapy. The following study investigated whether the inhibition of Flap Endonuclease 1 (FEN1) expression, the key enzyme in the base excision repair (BER) pathway, could improve the anti-tumor effect of arsenic trioxide (ATO), which is a reactive oxygen species (ROS) inducer. Our data showed that ATO could increase the expression of FEN1, and ...[more]