Dataset Information

Relationship between BRSK1 rs12611091 variant and age at natural menopause based on physical activity.

ABSTRACT: OBJECTIVES:The rs12611091 variant in the BR serine/threonine kinase 1 gene is one of the variants previously associated with age at natural menopause. So far, this variant has not been replicated in Taiwanese women. The purpose of this study was to determine the association between rs12611091 and age at natural menopause based on physical activity. METHODS:A total of 1,758 women were eligible for analysis whose information about menopause was collected from the Taiwan Biobank. Multiple linear regression analysis was used for analysis. RESULTS:The mean age (standard deviation) at natural menopause was 50.82 (3.59) years. Of the eligible participants, 56.94% were rs12611091 CC carriers, 36.69% were TC carriers, and 6.37% were TT carriers. Compared to CC carriers, TC and TT carriers were associated with early menopause (??=?-0.42, P?=?0.02 and -0.87, P?=?0.01, respectively). There was a significant interaction between rs12611091 and physical activity (P for interaction?=?0.02). Compared to rs12611091 CC carriers, TC and TT carriers who were physically inactive were significantly associated with earlier menopause (??=?-0.88, P?

SUBMITTER: Su CL

PROVIDER: S-EPMC7147414 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Relationship between BRSK1 rs12611091 variant and age at natural menopause based on physical activity.

Su Chun-Lang CL Tsai Yi-Ling YL Nfor Oswald Ndi ON Liu Wen-Hsiu WH Ho Chien Chang CC Lung Chia-Chi CC Lin Yi-Tien YT Wang Lee L Liaw Yung-Po YP

Menopause (New York, N.Y.) 20200401 4

<h4>Objectives</h4>The rs12611091 variant in the BR serine/threonine kinase 1 gene is one of the variants previously associated with age at natural menopause. So far, this variant has not been replicated in Taiwanese women. The purpose of this study was to determine the association between rs12611091 and age at natural menopause based on physical activity.<h4>Methods</h4>A total of 1,758 women were eligible for analysis whose information about menopause was collected from the Taiwan Biobank. Mul ...[more]

PMID: 31895179

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Project description:BackgroundAge at natural menopause (ANM) is considered as a biologic marker of health and ageing. The relationship between intimate partner violence (IPV) and ANM is currently unknown, and whether smoking plays a role in this relationship is unclear. The aim of this study was to examine the association between IPV and ANM and to quantify the effect mediated through smoking.MethodsData were drawn from the 1946-51 cohort of the Australian Longitudinal Study on Women's Health, a prospective cohort study first conducted in 1996. History of IPV (yes or no) was self-reported at baseline. ANM was confirmed by at least 12 months of cessation of menses where this was not a result of medical interventions such as bilateral oophorectomy or hysterectomy and categorised as <45 (early menopause), 45-49, 50-51, 52-53, and ≥54 years. Regression models and mediation analyses based on the counterfactual framework were performed to examine the relationship between IPV and ANM and to quantify the proportion mediated through smoking (never, past, current <10, 10-19 and ≥20 cigarettes/day).ResultsOf 6138 women in the study with natural menopause, 932 (15%) reported a history of IPV and 429 (7.0%) had an early ANM (before age 45 years). Women with IPV were more likely to smoke and be heavy smokers (Odds Ratio: 2.77, 95% CI 2.19-3.51). Women with IPV were also at increased risk of early menopause (ANM <45 years) (Relative Risk Ratio: 1.36, 95% CI 1.03-1.80) after accounting for education level, income difficulties, age at menarche, parity, body mass index, and perceived stress, compared to the reference group (women without IPV and ANM at 50-51 years). This relationship was attenuated after adjusting for smoking (Relative Risk Ratio: 1.20, 95% CI 0.90-1.59). Mediation analysis showed that cigarette smoking explained 36.7% of the association between IPV and early menopause (ANM <45 vs. ≥45 years).ConclusionCigarette smoking substantially mediated the relationship between IPV and early menopause. Findings suggest that as part of addressing the impact of IPV, timely interventions that result in cessation of smoking will partly mitigate the increased risk of early menopause.

Dataset Information

Relationship between BRSK1 rs12611091 variant and age at natural menopause based on physical activity.

Publications

Relationship between BRSK1 rs12611091 variant and age at natural menopause based on physical activity.

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