Ontology highlight
ABSTRACT:
SUBMITTER: Yang YC
PROVIDER: S-EPMC7150432 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Yang Yu-Chan YC Chen Yu-Hsiang YH Kao Jia-Horng JH Ching Chi C Liu I-Jung IJ Wang Chih-Chiang CC Tsai Cheng-Hsueh CH Wu Fang-Yi FY Liu Chun-Jen CJ Chen Pei-Jer PJ Chen Ding-Shinn DS Yang Hung-Chih HC
Molecular therapy. Nucleic acids 20200319
Current antiviral therapy fails to cure chronic hepatitis B virus (HBV) infection because of persistent covalently closed circular DNA (cccDNA). CRISPR/Cas9-mediated specific cleavage of cccDNA is a potentially curative strategy for chronic hepatitis B (CHB). However, the CRISPR/Cas system inevitably targets integrated HBV DNA and induces double-strand breaks (DSBs) of host genome, bearing the risk of genomic rearrangement and damage. Herein, we examined the utility of recently developed CRISPR/ ...[more]