Ontology highlight
ABSTRACT:
SUBMITTER: Rice S
PROVIDER: S-EPMC7150855 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Rice Sadie S Kim Seong-Man SM Rodriguez Cynthia C Songock William W Raikhy Gaurav G Lopez Rebecca R Henderson Lauren L Yusufji Arjun A Bodily Jason J
Viruses 20200313 3
Persistent infection by human papillomaviruses (HPVs), small, double-stranded DNA viruses that infect keratinocytes of the squamous epithelia, can lead to the development of cervical and other cancers. The viral oncoprotein E7 contributes to viral persistence in part by regulating host gene expression through binding host transcriptional regulators, although mechanisms responsible for E7-mediated transcriptional regulation are incompletely understood. Type I IFN signaling promotes the expression ...[more]