Ontology highlight
ABSTRACT:
SUBMITTER: Mikolcevic P
PROVIDER: S-EPMC3272973 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Mikolcevic Petra P Sigl Reinhard R Rauch Veronika V Hess Michael W MW Pfaller Kristian K Barisic Marin M Pelliniemi Lauri J LJ Boesl Michael M Geley Stephan S
Molecular and cellular biology 20111219 4
Cyclin-dependent kinase 16 (CDK16, PCTK1) is a poorly characterized protein kinase, highly expressed in the testis and the brain. Here, we report that CDK16 is activated by membrane-associated cyclin Y (CCNY). Treatment of transfected human cells with the protein kinase A (PKA) activator forskolin blocked, while kinase inhibition promoted, CCNY-dependent targeting of CDK16-green fluorescent protein (GFP) to the cell membrane. CCNY binding to CDK16 required a region upstream of the kinase domain ...[more]