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Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization.


ABSTRACT: Background:Mainland China has experienced five epidemics of human cases of avian influenza A(H7N9) virus infection since 2013. We conducted a prospective study to assess long-term clinical, pulmonary function testing, and chest computed tomography (CT) imaging findings after patients were discharged from hospital. Methods:A(H7N9) survivors in five provinces and one municipality underwent follow-up visits from August 2013 to September 2018, at three, six, and 12 months after illness onset, and a subset was also assessed at 18 and 64 months after onset. Thirteen patients were enrolled from the first A(H7N9) epidemic in 2013, 36 from the 2013-2014 second epidemic, and 12 from the 2016-2017 fifth epidemic. At each visit, A(H7N9) survivors received a medical examination, including the mMRC (modified Medical Research Council) dyspnea scale assessment, chest auscultation, pulmonary function testing and chest CT scans. Findings:The median age of 61 A(H7N9) survivors was 50 years. The cumulative rate of pulmonary dysfunction was 38·5% and 78·2% for chest CT scan abnormalities at the end of follow-up. Restrictive ventilation dysfunction was common during follow-up. Mild dyspnea was documented at three to 12-month follow-up visits. Interpretation:Patients who survived severe illness from A(H7N9) virus infection had evidence of persistent lung damage and long-term pulmonary dysfunction. Funding:National Science Fund for Distinguished Young Scholars (grant number 81525023); Program of Shanghai Academic/Technology Research Leader (grant number 18XD1400300); National Science and Technology Major Project of China (grant numbers 2017ZX10103009-005, 2018ZX10201001-010).

SUBMITTER: Wang Q 

PROVIDER: S-EPMC7152818 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Long-term clinical prognosis of human infections with avian influenza A(H7N9) viruses in China after hospitalization.

Wang Qianli Q   Jiang Hui H   Xie Yun Y   Zhang Tianchen T   Liu Shelan S   Wu Shenggen S   Sun Qianlai Q   Song Shaoxia S   Wang Wei W   Deng Xiaowei X   Ren Lingshuang L   Qin Tiantian T   Horby Peter P   Uyeki Timothy T   Yu Hongjie H  

EClinicalMedicine 20200219


<h4>Background</h4>Mainland China has experienced five epidemics of human cases of avian influenza A(H7N9) virus infection since 2013. We conducted a prospective study to assess long-term clinical, pulmonary function testing, and chest computed tomography (CT) imaging findings after patients were discharged from hospital.<h4>Methods</h4>A(H7N9) survivors in five provinces and one municipality underwent follow-up visits from August 2013 to September 2018, at three, six, and 12 months after illnes  ...[more]

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