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Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis.

ABSTRACT: Wheldone (1) was isolated and elucidated from a coculture of Aspergillus fischeri (NRRL 181) and Xylaria flabelliformis (G536), where secondary metabolite biosynthesis was stimulated by antagonism between these fungi. First observed via in situ analysis between these competing fungal cultures, the conditions were scaled to reproducibly generate 1, whose novel structure was elucidated by one- and two-dimensional NMR and mass spectrometry. Compound 1 displayed cytotoxic activity against breast, ovarian, and melanoma cancer cell lines.

SUBMITTER: Knowles SL

PROVIDER: S-EPMC7153779 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis.

Knowles Sonja L SL Raja Huzefa A HA Isawi Israa H IH Flores-Bocanegra Laura L Reggio Patricia H PH Pearce Cedric J CJ Burdette Joanna E JE Rokas Antonis A Oberlies Nicholas H NH

Organic letters 20200225 5

Wheldone (1) was isolated and elucidated from a coculture of Aspergillus fischeri (NRRL 181) and Xylaria flabelliformis (G536), where secondary metabolite biosynthesis was stimulated by antagonism between these fungi. First observed via in situ analysis between these competing fungal cultures, the conditions were scaled to reproducibly generate 1, whose novel structure was elucidated by one- and two-dimensional NMR and mass spectrometry. Compound 1 displ ...[more]

PMID: 32096649

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