STRIPAK Limits Stem Cell Differentiation of a WNT Signaling Center to Control Planarian Axis Scaling.
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ABSTRACT:
SUBMITTER: Schad EG
PROVIDER: S-EPMC7153782 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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STRIPAK Limits Stem Cell Differentiation of a WNT Signaling Center to Control Planarian Axis Scaling.
Schad Erik G EG Petersen Christian P CP
Current biology : CB 20200109 2
Regeneration involves regulating tissue proportionality across considerable size ranges through unknown mechanisms. In planarians, which scale reversibly over 40× through regeneration, we identify the Striatin-interacting phosphatase and kinase (STRIPAK) complex as a potent negative regulator of axis length. Inhibition of two proteins in the STRIPAK complex, mob4 and striatin, dramatically increased posterior length, through expansion of a posterior wnt1+ signaling center within midline muscle c ...[more]
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