Ontology highlight
ABSTRACT:
SUBMITTER: Han S
PROVIDER: S-EPMC7153846 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Han SeongJun S Chung Douglas C DC St Paul Michael M Liu Zhe Qi ZQ Garcia-Batres Carlos C Elford Alisha R AR Tran Charles W CW Chapatte Laurence L Ohashi Pamela S PS
Oncoimmunology 20200407 1
Regulatory T cells are integral to the regulation of autoimmune and anti-tumor immune responses. However, several studies have suggested that changes in T cell signaling networks can result in T cells that are resistant to the suppressive effects of regulatory T cells. Here, we investigated the role of Cbl-b, an E3 ubiquitin ligase, in establishing resistance to Treg-mediated suppression. We found that the absence of Cbl-b, a negative regulator of multiple TCR signaling pathways, rendered T cell ...[more]