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Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.

ABSTRACT: Despite expression of the high-affinity IL-2R, CD4(+)CD25(+) regulatory T cells (Tregs) are hypoproliferative upon IL-2R stimulation in vitro. However the mechanisms by which CD4(+)CD25(+) T cells respond to IL-2 signals are undefined. In this report, we examine the cellular and molecular responses of CD4(+)CD25(+) Tregs to IL-2. IL-2R stimulation results in a G(1) cell cycle arrest, cellular enlargement and increased cellular survival of CD4(+)CD25(+) T cells. We find a distinct pattern of IL-2R signaling in which the Janus kinase/STAT pathway remains intact, whereas IL-2 does not activate downstream targets of phosphatidylinositol 3-kinase. Negative regulation of phosphatidylinositol 3-kinase signaling and IL-2-mediated proliferation of CD4(+)CD25(+) T cells is inversely associated with expression of the phosphatase and tensin homologue deleted on chromosome 10, PTEN.

SUBMITTER: Bensinger SJ 

PROVIDER: S-EPMC2842445 | biostudies-literature | 2004 May

REPOSITORIES: biostudies-literature

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Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.

Bensinger Steven J SJ   Walsh Patrick T PT   Zhang Jidong J   Carroll Martin M   Parsons Ramon R   Rathmell Jeffrey C JC   Thompson Craig B CB   Burchill Matthew A MA   Farrar Michael A MA   Turka Laurence A LA  

Journal of immunology (Baltimore, Md. : 1950) 20040501 9

Despite expression of the high-affinity IL-2R, CD4(+)CD25(+) regulatory T cells (Tregs) are hypoproliferative upon IL-2R stimulation in vitro. However the mechanisms by which CD4(+)CD25(+) T cells respond to IL-2 signals are undefined. In this report, we examine the cellular and molecular responses of CD4(+)CD25(+) Tregs to IL-2. IL-2R stimulation results in a G(1) cell cycle arrest, cellular enlargement and increased cellular survival of CD4(+)CD25(+) T cells. We find a distinct pattern of IL-2  ...[more]

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