Ontology highlight
ABSTRACT:
SUBMITTER: Asnaghi MA
PROVIDER: S-EPMC7154140 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Asnaghi M Adelaide MA Power Laura L Barbero Andrea A Haug Martin M Köppl Ruth R Wendt David D Martin Ivan I
Frontiers in bioengineering and biotechnology 20200407
The definition of quality controls for cell therapy and engineered product manufacturing processes is critical for safe, effective, and standardized clinical implementation. Using the example context of cartilage grafts engineered from autologous nasal chondrocytes, currently used for articular cartilage repair in a phase II clinical trial, we outlined how gene expression patterns and generalized linear models can be introduced to define molecular signatures of identity, purity, and potency. We ...[more]