Ontology highlight
ABSTRACT:
SUBMITTER: Niu Z
PROVIDER: S-EPMC7154662 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Niu Zheng Z Prade Elke E Malideli Eleni E Hille Kathleen K Jussupow Alexander A Mideksa Yonatan G YG Yan Li-Mei LM Qian Chen C Fleisch Markus M Messias Ana C AC Sarkar Riddhiman R Sattler Michael M Lamb Don C DC Feige Matthias J MJ Camilloni Carlo C Kapurniotu Aphrodite A Reif Bernd B
Angewandte Chemie (International ed. in English) 20200128 14
Designed peptides derived from the islet amyloid polypeptide (IAPP) cross-amyloid interaction surface with Aβ (termed interaction surface mimics or ISMs) have been shown to be highly potent inhibitors of Aβ amyloid self-assembly. However, the molecular mechanism of their function is not well understood. Using solution-state and solid-state NMR spectroscopy in combination with ensemble-averaged dynamics simulations and other biophysical methods including TEM, fluorescence spectroscopy and microsc ...[more]