Ontology highlight
ABSTRACT:
SUBMITTER: Pairault N
PROVIDER: S-EPMC7154720 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Pairault Noël N Zhu Hui H Jansen Dennis D Huber Alexander A Daniliuc Constantin G CG Grimme Stefan S Niemeyer Jochen J
Angewandte Chemie (International ed. in English) 20200116 13
Heterobifunctional rotaxanes serve as efficient catalysts for the addition of malonates to Michael acceptors. We report a series of four different heterobifunctional rotaxanes, featuring an amine-based thread and a chiral 1,1'-binaphthyl-phosphoric-acid-based macrocycle. High-level DFT calculations provided mechanistic insights and enabled rational catalyst improvements, leading to interlocked catalysts that surpass their non-interlocked counterparts in terms of reaction rates and stereoselectiv ...[more]