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Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction.

ABSTRACT: A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU. This two-step one-pot procedure afforded the targeted tetramic acid analogues in good yields. With commercially available Ugi starting materials, microwave irradiation, a simple operation, excellent yields, and a broad scope, this reaction has the potential to produce a large number of tetramic acid analogues, which cannot be easily accessed by the classic synthetic methods.

SUBMITTER: Li Y

PROVIDER: S-EPMC7155898 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction.

Li Yong Y Huang Zheng Z Xu Jia J Ding Yong Y Tang Dian-Yong DY Lei Jie J Li Hong-Yu HY Chen Zhong-Zhu ZZ Xu Zhi-Gang ZG

Beilstein journal of organic chemistry 20200409

A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU. This two-step one-pot procedure afforded the targeted tetramic acid analogues in good yields. With commercially available Ugi starting materials, microwave irradiation, a simple operation, excellent yields, and a broad scope, this reaction has the potential to produce a large number of tetramic acid analogues, which cannot be easily accessed ...[more]

PMID: 32318123

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